Prokinetics in the management of functional gastrointestinal disorders Academic Article uri icon


MeSH Major

  • Algorithms
  • Gases
  • Imaging, Three-Dimensional
  • Lung Volume Measurements
  • Solitary Pulmonary Nodule
  • Tomography, X-Ray Computed


  • A variety of common and some not common gastrointestinal syndromes are thought to be based on impaired gut motility. For some, the role of motility is well defined, for others and the functional gastrointestinal disorders, in particular, the role of hy-po- or dysmotility remains unclear. Over the years pharmacological and physiological laboratories have developed drugs which stimulate gut motility; many have been evaluated in motility and functional disorders with what can best be described as mixed results. Lack of receptor specificity and resultant expected and unexpected adverse events have led to the demise of some of these agents. Newer, more selective agents offer promise but the heterogeneity of the clinical disorders they target continues to pose a formidable challenge to drug development in this area.

publication date

  • January 2015



  • Academic Article



  • eng

PubMed Central ID

  • PMC4496896

Digital Object Identifier (DOI)

  • 10.5056/jnm15094

PubMed ID

  • 26130629

Additional Document Info

start page

  • 330

end page

  • 6


  • 21


  • 3