Combinatorial strategies for the induction of immunogenic cell death Review uri icon

Overview

MeSH Major

  • Membrane Potential, Mitochondrial
  • Models, Biological
  • Necrosis
  • Signal Transduction

abstract

  • The term "immunogenic cell death" (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system. The inoculation of cancer cells undergoing ICD into immunocompetent animals elicits a specific immune response associated with the establishment of immunological memory. Only a few agents are intrinsically endowed with the ability to trigger ICD. These include a few chemotherapeutics that are routinely employed in the clinic, like doxorubicin, mitoxantrone, oxaliplatin, and cyclophosphamide, as well as some agents that have not yet been approved for use in humans. Accumulating clinical data indicate that the activation of adaptive immune responses against dying cancer cells is associated with improved disease outcome in patients affected by various neoplasms. Thus, novel therapeutic regimens that trigger ICD are urgently awaited. Here, we discuss current combinatorial approaches to convert otherwise non-immunogenic instances of RCD into bona fide ICD.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4408862

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2015.00187

PubMed ID

  • 25964783

Additional Document Info

start page

  • 187

volume

  • 6

number

  • APR