Microbial-Derived Lithocholic Acid and Vitamin K2 Drive the Metabolic Maturation of Pluripotent Stem Cells-Derived and Fetal Hepatocytes Academic Article uri icon

Overview

MeSH Major

  • Cell Culture Techniques
  • Hepatocytes
  • Lithocholic Acid
  • Pluripotent Stem Cells
  • Vitamin K 2

abstract

  • Our work provides fresh insights into liver development, suggesting that microbial-derived cues may drive the maturation of CYP450 enzymes postpartum. Addition of these cues results in the first functional, inducible, hPSC-derived hepatocyte for predictive toxicology.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/hep.27803

PubMed ID

  • 25808545

Additional Document Info

start page

  • 265

end page

  • 78

volume

  • 62

number

  • 1