Hepatitis C Virus Infects Rhesus Macaque Hepatocytes and Simianized Mice Academic Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Hepacivirus
  • Hepatitis C
  • Hepatocytes
  • Host-Pathogen Interactions

abstract

  • Together, these data indicate that rhesus macaques may be a viable model for HCV and implicate host immunity as a potential species-specific barrier to HCV infection. We conclude that suppression of host immunity or further viral adaptation may allow robust HCV infection in rhesus macaques and creation of a new animal model for studies of HCV pathogenesis, lentivirus coinfection, and vaccine development.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4482775

Digital Object Identifier (DOI)

  • 10.1002/hep.27773

PubMed ID

  • 25820364

Additional Document Info

start page

  • 57

end page

  • 67

volume

  • 62

number

  • 1