Neutrophil-related gene expression and low-density granulocytes associated with disease activity and response to treatment in antineutrophil cytoplasmic antibody-associated vasculitis Academic Article uri icon

Overview

MeSH Major

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
  • Granulocytes
  • Leukocyte Elastase
  • Myeloblastin
  • Peroxidase

abstract

  • In AAV, increased expression of a granulocyte gene signature is associated with disease activity and decreased response to treatment. The source of this signature is likely LDGs, a potentially pathogenic cell type in AAV.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4485551

Digital Object Identifier (DOI)

  • 10.1002/art.39153

PubMed ID

  • 25891759

Additional Document Info

start page

  • 1922

end page

  • 32

volume

  • 67

number

  • 7