High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium Academic Article uri icon

Overview

MeSH Major

  • Breast
  • Breast Neoplasms
  • Collagen
  • Epithelium
  • Mammary Glands, Human
  • Stromal Cells

abstract

  • We confirmed increased proportions of stroma and epithelium, increased aromatase activity and no changes in hormone receptor or Ki-67 marker status in HMD tissue. The HMD region showed increased collagen deposition and organisation as well as decreased alternatively activated macrophages in the stroma. The HMD epithelium may be a site for local inflammation, as we observed a significant increase in CD45(+)/vimentin(+) immune cells in this area.

publication date

  • June 4, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4485361

Digital Object Identifier (DOI)

  • 10.1186/s13058-015-0592-1

PubMed ID

  • 26040322

Additional Document Info

start page

  • 79

volume

  • 17

number

  • 1