HIF-1α and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages Academic Article uri icon

Overview

MeSH Major

  • Atherosclerosis
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Macrophages
  • Phosphofructokinase-2

abstract

  • These findings, in human and murine cells and in an animal model, show that hypoxia potentiates macrophage glycolytic flux in concert with a proportional upregulation of proinflammatory activity, in a manner that is dependent on both hypoxia-inducible factor -1α and 6-phosphofructo-2-kinase.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4441599

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.115.305551

PubMed ID

  • 25882065

Additional Document Info

start page

  • 1463

end page

  • 71

volume

  • 35

number

  • 6