Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas Academic Article uri icon

Overview

MeSH Major

  • DNA, Neoplasm
  • Genes, p53
  • Glioma
  • Mutation

abstract

  • The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class. Lower-grade gliomas with an IDH mutation either had 1p/19q codeletion or carried a TP53 mutation. Most lower-grade gliomas without an IDH mutation were molecularly and clinically similar to glioblastoma. (Funded by the National Institutes of Health.).

authors

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4530011

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1402121

PubMed ID

  • 26061751

Additional Document Info

start page

  • 2481

end page

  • 98

volume

  • 372

number

  • 26