Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells Academic Article uri icon

Overview

MeSH Major

  • Bacteria
  • CD4-Positive T-Lymphocytes
  • Colon
  • Histocompatibility Antigens Class II
  • Immunity, Innate
  • Inflammatory Bowel Diseases

abstract

  • Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD.

publication date

  • May 29, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4449822

Digital Object Identifier (DOI)

  • 10.1126/science.aaa4812

PubMed ID

  • 25908663

Additional Document Info

start page

  • 1031

end page

  • 5

volume

  • 348

number

  • 6238