Acetyl coenzyme A: A central metabolite and second messenger Review uri icon

Overview

MeSH Major

  • Acetyl Coenzyme A
  • Autophagy
  • Energy Metabolism
  • Epigenesis, Genetic
  • Mitosis
  • Second Messenger Systems

abstract

  • Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the cell. Moreover, acetyl-CoA concentrations influence the activity or specificity of multiple enzymes, either in an allosteric manner or by altering substrate availability. Finally, by influencing the acetylation profile of several proteins, including histones, acetyl-CoA controls key cellular processes, including energy metabolism, mitosis, and autophagy, both directly and via the epigenetic regulation of gene expression. Thus, acetyl-CoA determines the balance between cellular catabolism and anabolism by simultaneously operating as a metabolic intermediate and as a second messenger.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2015.05.014

PubMed ID

  • 26039447

Additional Document Info

start page

  • 805

end page

  • 21

volume

  • 21

number

  • 6