Chronic infection by mucoid pseudomonas aeruginosa associated with dysregulation in T-cell immunity to outer membrane porin F Academic Article uri icon

Overview

MeSH Major

  • Lung
  • Porins
  • Pseudomonas Infections
  • Pseudomonas aeruginosa
  • T-Lymphocytes

abstract

  • We have defined the immunodominant, HLA-restricted T-cell epitopes of OprF. Our observation that chronic infection is associated with a response of narrowed specificity, despite strong innate and antibody immunity, may help to explain susceptibility in these individuals and pave the way for better vaccine design to achieve protective immunity.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4476516

Digital Object Identifier (DOI)

  • 10.1164/rccm.201411-1995OC

PubMed ID

  • 25789411

Additional Document Info

start page

  • 1250

end page

  • 64

volume

  • 191

number

  • 11