Sex steroid ablation: An immunoregenerative strategy for immunocompromised patients Review uri icon

Overview

MeSH Major

  • Aging
  • Gonadal Steroid Hormones
  • Immunocompromised Host
  • Immunotherapy
  • Regenerative Medicine
  • Thymus Gland

abstract

  • Age-related decline in thymic function is a well-described process that results in reduced T-cell development and thymic output of new na├»ve T cells. Thymic involution leads to reduced response to vaccines and new pathogens in otherwise healthy individuals; however, reduced thymic function is particularly detrimental in clinical scenarios where the immune system is profoundly depleted such as after chemotherapy, radiotherapy, infection and shock. Poor thymic function and restoration of immune competence has been correlated with an increased risk of opportunistic infections, tumor relapse and autoimmunity. Apart from their primary role in sex dimorphism, sex steroid levels profoundly affect the immune system in general and, in fact, age-related thymic involution has been at least partially attributed to the increase in sex steroids at puberty. Subsequently it has been demonstrated that the removal of sex steroids, or sex steroid ablation (SSA), triggers physiologic changes that ultimately lead to thymic re-growth and improved T-cell reconstitution in settings of hematopoietic stem cell transplant (HSCT). Although the cellular and molecular process underlying these regenerative effects are still poorly understood, SSA clearly represents an attractive therapeutic approach to enhance thymic function and restore immune competence in immunodeficient individuals.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5067941

Digital Object Identifier (DOI)

  • 10.1038/bmt.2015.101

PubMed ID

  • 26039214

Additional Document Info

start page

  • S77

end page

  • 81

volume

  • 50