MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus Academic Article uri icon

Overview

MeSH Major

  • Acetazolamide
  • Hydrocephalus, Normal Pressure

abstract

  • Kaolin-hydrocephalus can accelerate intraneuronal Aβ40 accumulation and vascular pathology in tgAPP21 rats. In addition, disrupted CSF production and reduced CSF turnover results in impaired Aβ clearance and accelerated vascular pathology in chronic hydrocephalus. The high co-morbidity seen in NPH, AD and CVD is likely not to be an age-related coincidence, but rather a convergence of pathologies related to diminished CSF clearance.

publication date

  • April 2, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4432506

Digital Object Identifier (DOI)

  • 10.1186/s12987-015-0004-z

PubMed ID

  • 25928394

Additional Document Info

start page

  • 2

volume

  • 12

number

  • 1