Pericytes, microvasular dysfunction, and chronic rejection Review uri icon

Overview

MeSH Major

  • Graft Rejection
  • Microcirculation
  • Microvessels
  • Organ Transplantation
  • Pericytes

abstract

  • Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4455035

Digital Object Identifier (DOI)

  • 10.1097/TP.0000000000000648

PubMed ID

  • 25793439

Additional Document Info

start page

  • 658

end page

  • 67

volume

  • 99

number

  • 4