Vasculitis and pregnancy
© 2014 Springer Science+Business Media New York. All rights are reserved.Several of the primary systemic vasculitides including those involving large, medium, and small blood vessels can affect women of childbearing age. In approaching pregnancy in any woman with an underlying primary vasculitis, thorough assessment of disease activity and prior damage is crucial. In all forms of vasculitis, both maternal and fetal outcomes are optimized when the vasculitis is in remission at the time of conception. While the data are limited, pregnancy itself does not seem to cause disease flares in the majority of women with any of the primary vasculitides. Rates of maternal complications vary depending on the type of vasculitis, with most maternal complications related to sequelae of prior vasculitis in the form of hypertension, renal insufficiency, or airway disease. There are few reports of transient manifestations of vasculitis in neonates, presumed to be related to trans-placental transfer of antibodies, all of which were self-limited.
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