A genome-wide association study of marginal zone lymphoma shows association to the HLA region Academic Article uri icon

Overview

MeSH Major

  • European Continental Ancestry Group
  • Lymphoma, B-Cell, Marginal Zone
  • Major Histocompatibility Complex
  • Membrane Glycoproteins
  • Polymorphism, Single Nucleotide

abstract

  • Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

authors

publication date

  • January 8, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4287989

Digital Object Identifier (DOI)

  • 10.1038/ncomms6751

PubMed ID

  • 25569183

Additional Document Info

start page

  • 5751

volume

  • 6