Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of MicroRNA-92a Academic Article uri icon

Overview

MeSH Major

  • Endothelium, Vascular
  • Immunity, Innate
  • Inflammasomes
  • MicroRNAs
  • Oxidative Stress
  • Sterol Regulatory Element Binding Protein 2
  • Transcriptional Activation

abstract

  • Our findings suggest that SREBP2-miR-92a-inflammasome exacerbates endothelial dysfunction during oxidative stress. Identification of this mechanism may help in the diagnosis or treatment of disorders associated with oxidative stress, innate immune activation, and endothelial dysfunction.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4351177

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.114.013675

PubMed ID

  • 25550450

Additional Document Info

start page

  • 805

end page

  • 14

volume

  • 131

number

  • 9