Chemotherapy and novel therapeutics before radical prostatectomy for high-risk clinically localized prostate cancer Review uri icon


MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Neoadjuvant Therapy
  • Prostatectomy
  • Prostatic Neoplasms


  • Although both surgery and radiation are potential curative options for men with clinically localized prostate cancer, a significant proportion of men with high-risk and locally advanced disease will demonstrate biochemical and potentially clinical progression of their disease. Neoadjuvant systemic therapy before radical prostatectomy (RP) is a logical strategy to improve treatment outcomes for men with clinically localized high-risk prostate cancer. Furthermore, delivery of chemotherapy and other systemic agents before RP affords an opportunity to explore the efficacy of these agents with pathologic end points. Neoadjuvant chemotherapy, primarily with docetaxel (with or without androgen deprivation therapy), has demonstrated feasibility and safety in men undergoing RP, but no study to date has established the efficacy of neoadjuvant chemotherapy or neoadjuvant chemohormonal therapies. Other novel agents, such as those targeting the vascular endothelial growth factor receptor, epidermal growth factor receptor, platelet-derived growth factor receptor, clusterin, and immunomodulatory therapeutics, are currently under investigation.

publication date

  • January 2015



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.urolonc.2014.11.020

PubMed ID

  • 25596644

Additional Document Info

start page

  • 217

end page

  • 25


  • 33


  • 5