Mitochondrial ROS metabolism: 10 Years later Review uri icon

Overview

MeSH Major

  • Antioxidants
  • Mitochondria
  • Mitochondrial Proteins
  • Reactive Oxygen Species

abstract

  • The role of mitochondria in oxidative stress is well recognized, but many questions are still to be answered. This article is intended to update our comprehensive review in 2005 by highlighting the progress in understanding of mitochondrial reactive oxygen species (ROS) metabolism over the past 10 years. We review the recently identified or re-appraised sources of ROS generation in mitochondria, such as p66(shc) protein, succinate dehydrogenase, and recently discovered properties of the mitochondrial antioxidant system. We also reflect upon some controversies, disputes, and misconceptions that confound the field.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4511471

Digital Object Identifier (DOI)

  • 10.1134/S0006297915050028

PubMed ID

  • 26071769

Additional Document Info

start page

  • 517

end page

  • 31

volume

  • 80

number

  • 5