Role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome Academic Article uri icon

Overview

MeSH Major

  • Atypical Hemolytic Uremic Syndrome
  • Complement Membrane Attack Complex
  • Microvessels
  • Skin

abstract

  • In a clinical setting where aHUS is an important diagnostic consideration, extensive microvascular deposition of C5b-9 supports the diagnosis of either aHUS or a subset of thrombotic thrombocytopenic purpura patients with concomitant complement dysregulation; significant vascular C5b-9 deposition predicts clinical responsiveness to eculizumab.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4405909

Digital Object Identifier (DOI)

  • 10.1097/DAD.0000000000000234

PubMed ID

  • 25893747

Additional Document Info

start page

  • 349

end page

  • 59

volume

  • 37

number

  • 5