Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Human Umbilical Vein Endothelial Cells
  • Mesoderm
  • Receptors, Notch
  • Tumor Microenvironment

abstract

  • Overall, our data proposed a crosstalk mechanism between tumor and microenvironment where tumor-stimulated mesenchymal modulation of ECs enhanced the constitution of a transient mesenchymal/endothelial niche leading to significant increase in tumor proliferation, stemness, and invasiveness. The possible involvement of notch and TGFβ pathways in the initiation of mesenchymal phenotype may propose new stromal targets.

publication date

  • January 27, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4336716

Digital Object Identifier (DOI)

  • 10.1186/s12967-015-0386-3

PubMed ID

  • 25623554

Additional Document Info

start page

  • 27

volume

  • 13

number

  • 1