Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Carcinoma, Lobular
  • Genes, BRCA1
  • Genes, BRCA2

abstract

  • Differences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER-positive and ER-negative tumors. Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction.

authors

publication date

  • December 31, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4406179

Digital Object Identifier (DOI)

  • 10.1186/s13058-014-0492-9

PubMed ID

  • 25919761

Additional Document Info

start page

  • 3416

volume

  • 16