Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Heart Diseases
  • Receptor, ErbB-2
  • Trastuzumab

abstract

  • The Her2/neu Pro 1170 Ala polymorphism can be used to identify a subset of patients who are at increased risk of cardiotoxicity from trastuzumab therapy. Her2/neu single nucleotide polymorphisms may be useful in conjunction with other biomarkers to risk stratify patients in order to optimize clinical management.

publication date

  • April 11, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4403678

Digital Object Identifier (DOI)

  • 10.1186/s12885-015-1298-6

PubMed ID

  • 25885598

Additional Document Info

start page

  • 267

volume

  • 15

number

  • 1