Cell-type specific expression of p11 controls cocaine reward Academic Article uri icon

Overview

MeSH Major

  • Annexin A2
  • Cocaine
  • Conditioning (Psychology)
  • Neurons
  • Nucleus Accumbens
  • Reward
  • S100 Proteins

abstract

  • Our data provide evidence that disruption of p11 homeostasis in the NAc, particularly in dopamine receptor-1 expressing medium spiny neurons, may underlie pathophysiological mechanisms of cocaine rewarding action. Treatments to counter maladaptation of p11 levels may provide novel therapeutic opportunities for cocaine addiction.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4145045

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2014.02.012

PubMed ID

  • 24725970

Additional Document Info

start page

  • 794

end page

  • 801

volume

  • 76

number

  • 10