Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling Academic Article uri icon

Overview

MeSH Major

  • Alternative Splicing
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Neovascularization, Pathologic
  • Plaque, Atherosclerotic
  • Signal Transduction
  • Thromboplastin
  • Vascular Endothelial Growth Factor A

abstract

  • The results of this study provide strong evidence that asTF promotes neointima formation and angiogenesis in an experimental model of accelerated atherosclerosis. Here, we demonstrate that the angiogenic effect of asTF is mediated via the activation of the hypoxia-inducible factor-1/vascular endothelial growth factor signaling. This mechanism may be relevant to neovascularization and the progression and associated complications of human atherosclerosis as suggested by the increased expression of asTF in complicated versus uncomplicated human carotid and coronary plaques.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4190117

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.114.006614

PubMed ID

  • 25116956

Additional Document Info

start page

  • 1274

end page

  • 86

volume

  • 130

number

  • 15