MAP2K1 (MEK1) mutations define a distinct subset of lung adenocarcinoma associated with smoking Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Lung Neoplasms
  • MAP Kinase Kinase 1
  • Mutation
  • Smoking

abstract

  • MEK1 mutations define a distinct subset of lung cancers (∼1%) with potential sensitivity to MEK inhibitors. Mutations are predominantly transversions, in keeping with a strong association with smoking. Clin Cancer Res; 21(8); 1935-43. ©2014 AACR.

publication date

  • April 15, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4401580

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-14-2124

PubMed ID

  • 25351745

Additional Document Info

start page

  • 1935

end page

  • 43

volume

  • 21

number

  • 8