RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Colorectal Neoplasms
  • GTP Phosphohydrolases
  • Membrane Proteins
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins
  • ras Proteins

abstract

  • The metastatic potential of CRC varies with the presence of RAS mutation. RAS mutation is associated with worse OS and increased incidence of lung, bone, and brain metastasis. An understanding of this site-specific pattern of spread may help to inform physicians' assessment of symptoms in patients with mCRC.

publication date

  • April 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4523078

Digital Object Identifier (DOI)

  • 10.1002/cncr.29196

PubMed ID

  • 25491172

Additional Document Info

start page

  • 1195

end page

  • 203

volume

  • 121

number

  • 8