Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Angiopoietin-2
  • Carcinoma, Renal Cell
  • Indoles
  • Kidney Neoplasms
  • Matrix Metalloproteinase 2
  • Pyrroles
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-3
  • Von Hippel-Lindau Tumor Suppressor Protein

abstract

  • Serum Ang-2 and MMP-2 and tumor HIF-1α were identified as relevant baseline biomarkers of sunitinib activity in advanced RCC, warranting further research into their prognostic versus predictive value.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4175044

Digital Object Identifier (DOI)

  • 10.1007/s00280-014-2539-0

PubMed ID

  • 25100134

Additional Document Info

start page

  • 739

end page

  • 50

volume

  • 74

number

  • 4