Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor- beta1 in pulmonary fibrosis Academic Article uri icon

Overview

MeSH Major

  • Epithelial Cells
  • Mitochondria
  • Protein Kinases
  • Pulmonary Fibrosis
  • Transforming Growth Factor beta1

abstract

  • TGF-β1 induces lung epithelial cell mitochondrial ROS and depolarization and stabilizes the key mitophagy initiating protein, PINK1. PINK1 ameliorates epithelial cell death and may be necessary to limit fibrogenesis.

publication date

  • March 18, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4364993

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0121246

PubMed ID

  • 25785991

Additional Document Info

start page

  • e0121246

volume

  • 10

number

  • 3