Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. Academic Article uri icon

Overview

MeSH

  • Aged
  • Cohort Studies
  • Databases, Factual
  • Female
  • Humans
  • Incidence
  • Intraoperative Care
  • Male
  • Middle Aged
  • Minnesota
  • Retrospective Studies
  • Risk Factors
  • Sex Distribution
  • Shock
  • Treatment Outcome

MeSH Major

  • Blood Transfusion
  • Blood Volume
  • Perioperative Care
  • Transfusion Reaction

abstract

  • Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology. In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design. A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5% (119 of 2,162) in 2004 versus 3.0% (57 of 1,908) in 2011 (P < 0.001), with comparable rates for men (4.8% [98 of 2,023]) and women (3.8% [78 of 2,047]) (P = 0.09). Overall, vascular (12.1% [60 of 497]), transplant (8.8% [17 of 193]), and thoracic surgeries (7.2% [10 of 138]) carried the highest TACO rates. Obstetric and gynecologic patients had the lowest rate (1.4% [4 of 295]). The incidence of TACO increased with volume transfused, advancing age, and total intraoperative fluid balance (all P < 0.001). The incidence of perioperative TACO is similar to previous estimates in nonsurgical populations. There was a reduction in TACO rate between 2004 and 2011, with incidence patterns remaining comparable in subgroup analyses. Future efforts exploring risk factors for TACO may guide preventive or therapeutic interventions, helping to further mitigate this transfusion complication.

publication date

  • January 2015

has subject area

  • Aged
  • Blood Transfusion
  • Blood Volume
  • Cohort Studies
  • Databases, Factual
  • Female
  • Humans
  • Incidence
  • Intraoperative Care
  • Male
  • Middle Aged
  • Minnesota
  • Perioperative Care
  • Retrospective Studies
  • Risk Factors
  • Sex Distribution
  • Shock
  • Transfusion Reaction
  • Treatment Outcome

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4857710

Digital Object Identifier (DOI)

  • 10.1097/ALN.0000000000000513

PubMed ID

  • 25611653

Additional Document Info

start page

  • 21

end page

  • 28

volume

  • 122

number

  • 1