Transdifferentiation of human fibroblasts to endothelial cells role of innate immunity Academic Article uri icon

Overview

MeSH Major

  • Cell Transdifferentiation
  • Endothelial Cells
  • Fibroblasts
  • Immunity, Innate

abstract

  • This study suggests that manipulation of innate immune signaling may be generally used to modify cell fate. Because similar signaling pathways are activated by damage-associated molecular patterns, epigenetic plasticity induced by innate immunity may play a fundamental role in transdifferentiation during wound healing and regeneration. Finally, this study is a first step toward development of a small-molecule strategy for therapeutic transdifferentiation for vascular disease.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4309381

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.113.007394

PubMed ID

  • 25359165

Additional Document Info

start page

  • 300

end page

  • 9

volume

  • 131

number

  • 3