Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution Academic Article uri icon

Overview

MeSH Major

  • Immunoconjugates
  • Immunoglobulin G
  • Prostatic Neoplasms

abstract

  • We demonstrated that the choice of immunodeficient mouse model importantly influence the bio-distribution of (111)In-DTPA-5A10. This study further highlighted important considerations in the evaluation of preclinical tracers, with respect to gaining information on their performance in the translational setting. Investigators utilizing xenograft models need to assess not only radiolabeling strategies, but also the host immunological status.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4472383

Digital Object Identifier (DOI)

  • 10.1016/j.nucmedbio.2014.12.012

PubMed ID

  • 25577038

Additional Document Info

start page

  • 375

end page

  • 80

volume

  • 42

number

  • 4