Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade Academic Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Gonadal Steroid Hormones
  • Hematopoietic Stem Cells
  • Lymphopoiesis
  • Regeneration

abstract

  • Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation (HSCT). We herein show that, mechanistically, SSA induces hematopoietic and lymphoid recovery by functionally enhancing both HSC self-renewal and propensity for lymphoid differentiation through intrinsic molecular changes. Our transcriptome analysis revealed further hematopoietic support through rejuvenation of the bone marrow (BM) microenvironment, with upregulation of key hematopoietic factors and master regulatory factors associated with aging such as Foxo1. These studies provide important cellular and molecular insights into understanding how SSA-induced regeneration of the hematopoietic compartment can underpin recovery of the immune system following damaging cytoablative treatments. These findings support a short-term strategy for clinical use of SSA to enhance the production of lymphoid cells and HSC engraftment, leading to improved outcomes in adult patients undergoing HSCT and immune depletion in general.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4375937

Digital Object Identifier (DOI)

  • 10.1016/j.stemcr.2015.01.018

PubMed ID

  • 25733018

Additional Document Info

start page

  • 445

end page

  • 58

volume

  • 4

number

  • 3