Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas
Lymphoma, Large B-Cell, Diffuse
Neoplasm Recurrence, Local
Altogether, our study for the first time provides important evidence that DLBCL relapse may result from multiple, distinct tumor evolutionary mechanisms, providing rationale for therapies for each mechanism. Moreover, this study highlights the urgent need to understand the driving roles of epigenetic modifier mutations in lymphomagenesis, and immune surveillance factor genetic lesions in relapse.