Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas Academic Article uri icon

Overview

MeSH Major

  • Clonal Evolution
  • DNA-Binding Proteins
  • Lymphoma, Large B-Cell, Diffuse
  • Neoplasm Proteins
  • Neoplasm Recurrence, Local

abstract

  • Altogether, our study for the first time provides important evidence that DLBCL relapse may result from multiple, distinct tumor evolutionary mechanisms, providing rationale for therapies for each mechanism. Moreover, this study highlights the urgent need to understand the driving roles of epigenetic modifier mutations in lymphomagenesis, and immune surveillance factor genetic lesions in relapse.

publication date

  • August 15, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4158101

Digital Object Identifier (DOI)

  • 10.1186/s13059-014-0432-0

PubMed ID

  • 25123191

Additional Document Info

start page

  • 432

volume

  • 15

number

  • 8