Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve Academic Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Mitochondria
  • Mitochondrial Degradation
  • Optic Nerve

abstract

  • Decreased surface area, combined with reduced oxidative capacity in mitochondria from the aged DBA/2J axon, indicate that mitochondrial pathology may contribute to the energy deficit in glaucomatous optic nerve. Though autophagosomes were increased in DBA/2J optic nerve, the increased mitochondria and decreased LAMP1 suggest deteriorating mitochondria are not being efficiently recycled by mitophagy.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4347310

Digital Object Identifier (DOI)

  • 10.1167/iovs.14-16126

PubMed ID

  • 25655803

Additional Document Info

start page

  • 1437

end page

  • 46

volume

  • 56

number

  • 3