Esophageal and esophagogastric junction cancers, Version 1.2015 Review uri icon

Overview

MeSH Major

  • Esophageal Neoplasms
  • Esophagogastric Junction
  • Stomach Neoplasms

abstract

  • Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ.

authors

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 25691612

Additional Document Info

start page

  • 194

end page

  • 227

volume

  • 13

number

  • 2