Inhibition of vascular endothelial growth factor a and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature Academic Article uri icon

Overview

MeSH Major

  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Neovascularization, Pathologic
  • RNA, Small Interfering
  • Sarcoma, Experimental
  • Vascular Endothelial Growth Factor A

abstract

  • Inhibition of HIF-1α is highly effective when combined with RT and VEGF-A inhibition in blocking sarcoma growth by maximizing DNA damage and apoptosis in tumor ECs, leading to loss of tumor vasculature.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4559849

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2014.10.047

PubMed ID

  • 25544668

Additional Document Info

start page

  • 621

end page

  • 30

volume

  • 91

number

  • 3