Inhibition of vascular endothelial growth factor a and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature
Hypoxia-Inducible Factor 1, alpha Subunit
RNA, Small Interfering
Vascular Endothelial Growth Factor A
Inhibition of HIF-1α is highly effective when combined with RT and VEGF-A inhibition in blocking sarcoma growth by maximizing DNA damage and apoptosis in tumor ECs, leading to loss of tumor vasculature.