Controlling ionotropic and metabotropic glutamate receptors with light: Principles and potential Review uri icon

Overview

MeSH Major

  • Light
  • Receptors, Ionotropic Glutamate
  • Receptors, Metabotropic Glutamate

abstract

  • Light offers unique advantages for studying and manipulating biomolecules and the cellular processes that they control. Optical control of ionotropic and metabotropic glutamate receptors has garnered significant interest, since these receptors are central to signaling at neuronal synapses and only optical approaches provide the spatial and temporal resolution required to directly probe receptor function in cells and tissue. Following the classical method of glutamate photo-uncaging, recently developed methods have added other forms of remote control, including those with high molecular specificity and genetic targeting. These tools open the door to the direct optical control of synaptic transmission and plasticity, as well as the probing of native receptor function in intact neural circuits.

publication date

  • January 2015

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4318769

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2014.12.008

PubMed ID

  • 25573450

Additional Document Info

start page

  • 135

end page

  • 43

volume

  • 20