Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders Academic Article uri icon

Overview

MeSH Major

  • Histiocytosis
  • Mutation
  • Proto-Oncogene Proteins B-raf

abstract

  • Patients with BRAF(V600E)-mutant histiocytic disorders have remarkable responses to RAF inhibition, but mutation detection in tissue in these disorders is challenging. Here, we identify that analysis of plasma and urinary cfDNA provides a reliable method to detect the BRAF(V600E) mutation and monitor response to therapy in these disorders.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-14-0742

PubMed ID

  • 25324352

Additional Document Info

start page

  • 64

end page

  • 71

volume

  • 5

number

  • 1