Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations Academic Article uri icon

Overview

MeSH Major

  • Genetic Predisposition to Disease
  • Germ-Line Mutation
  • Lung Neoplasms
  • Receptor, Epidermal Growth Factor
  • Smoking

abstract

  • Germline T790M mutations result in a unique hereditary lung cancer syndrome that targets never smokers, with a preliminary estimate of 31% risk for lung cancer in never smoker carriers, and this risk may be lower for heavy smokers. The resultant cancers share several features and differences with lung cancers containing sporadic EGFR mutations.

publication date

  • April 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4509739

Digital Object Identifier (DOI)

  • 10.1097/JTO.0000000000000130

PubMed ID

  • 24736066

Additional Document Info

start page

  • 456

end page

  • 63

volume

  • 9

number

  • 4