Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations
Genetic Predisposition to Disease
Receptor, Epidermal Growth Factor
Germline T790M mutations result in a unique hereditary lung cancer syndrome that targets never smokers, with a preliminary estimate of 31% risk for lung cancer in never smoker carriers, and this risk may be lower for heavy smokers. The resultant cancers share several features and differences with lung cancers containing sporadic EGFR mutations.