Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: A prospective study Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Brain Neoplasms
  • Breast Neoplasms
  • Deoxycytidine
  • Fluorouracil
  • Quinazolines

abstract

  • This is the first study to demonstrate that capecitabine and lapatinib penetrate to a significant though variable degree in human BCBM. Drug delivery to BCBM is variable and in many cases appears partially limiting. Elucidating mechanisms that limit drug concentration and innovative approaches to overcome limited drug uptake will be important to improve clinical efficacy of these agents in the central nervous system. Trial registration ID: NCT00795678.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4288517

Digital Object Identifier (DOI)

  • 10.1093/neuonc/nou141

PubMed ID

  • 25015089

Additional Document Info

start page

  • 289

end page

  • 95

volume

  • 17

number

  • 2