Long-term repetitive transcranial magnetic stimulation therapy: New research questions arising from one tinnitus case? Academic Article uri icon


MeSH Major

  • Tinnitus
  • Transcranial Magnetic Stimulation


  • Tinnitus may become refractory to treatment and disabling. Brain transcranial magnetic stimulation (TMS) has shown promise as a therapy, but has been employed primarily short-term. We treated a patient with 5 weeks of weekly repetitive TMS (rTMS), followed by 6 months of monthly rTMS. He was a 75-year-old dentist with chronic tinnitus from occupational noise exposure. Physical examination and MRIs of the auditory canals and brain had revealed no lesions. The patient showed a general gradual, progressive improvement on per cent of severe tinnitus diary days (from baseline 100% to 33%), tinnitus handicap inventory (from baseline score 70 to 18), and mini-tinnitus questionnaire (from baseline score 17 to 6). No changes occurred in serial audiograms. Transient adverse events were a headache during stimulation, and dizziness 30 min after treatment. Implications and questions for future non-invasive neuromodulation clinical research raised by our case are discussed.

publication date

  • December 23, 2014



  • Academic Article



  • eng

PubMed Central ID

  • PMC4275713

Digital Object Identifier (DOI)

  • 10.1136/bcr-2014-207203

PubMed ID

  • 25538216

Additional Document Info


  • 2014