Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion Academic Article uri icon

Overview

MeSH Major

  • Cytomegalovirus Retinitis
  • Immunotherapy, Adoptive
  • Phosphoproteins
  • T-Lymphocytes, Cytotoxic
  • Viral Matrix Proteins

abstract

  • Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4373317

Digital Object Identifier (DOI)

  • 10.3928/23258160-20150101-14

PubMed ID

  • 25559515

Additional Document Info

start page

  • 80

end page

  • 2

volume

  • 46

number

  • 1