Comparing comparators: A look at control arms in kidney cancer studies over the years Review uri icon


MeSH Major

  • Antineoplastic Agents
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Randomized Controlled Trials as Topic


  • In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control arms: interferon alpha-2a or sorafenib. Different from expectations, the final results of some of these studies were not in line with the predictions, and the reasons have not been fully investigated. Consequently, there is a great need for careful analysis of the studies carried out so far, chiefly the role and validity of the control arms. In this regard, the examination of patient baseline characteristics and other factors of potential interest seems fundamental for a correct analysis of the results of these trials and consequent optimal use of the available targeted agents.

publication date

  • January 2015



  • Review



  • eng

PubMed Central ID

  • PMC4453592

Digital Object Identifier (DOI)

  • 10.1038/bjc.2014.240

PubMed ID

  • 25375270

Additional Document Info

start page

  • 14

end page

  • 9


  • 112


  • 1