Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: Leaky RyR2 channels under non-stress conditions Academic Article uri icon

Overview

MeSH Major

  • DNA
  • Mutation
  • Rest
  • Ryanodine Receptor Calcium Release Channel
  • Tachycardia, Ventricular

abstract

  • The RyR2-H29D mutation is associated with a clinical phenotype of short-coupled PMVT at rest. In contrast to catecholaminergic PMVT-associated RyR2 mutations, RyR2-H29D causes a leaky channel at diastolic levels of Ca(2+) under non-stress conditions. Leaky RyR2 may be an under-recognized mechanism for idiopathic PMVT at rest.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4281514

Digital Object Identifier (DOI)

  • 10.1016/j.ijcard.2014.11.119

PubMed ID

  • 25463374

Additional Document Info

start page

  • 228

end page

  • 36

volume

  • 180