Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation
Diabetes Mellitus, Experimental
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Vascular Endothelial Growth Factor Receptor-2
Our study demonstrated that PTP1B negatively modulated the diabetic wound healing process by dephosphorylating the endothelial cell vascular endothelial growth factor receptor 2 and that the specific inhibitor of PTP1B might serve as a potential novel therapeutic tool for diabetic wound healing.