Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Experimental
  • Diabetic Angiopathies
  • Endothelial Cells
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Skin Ulcer
  • Vascular Endothelial Growth Factor Receptor-2
  • Wound Healing

abstract

  • Our study demonstrated that PTP1B negatively modulated the diabetic wound healing process by dephosphorylating the endothelial cell vascular endothelial growth factor receptor 2 and that the specific inhibitor of PTP1B might serve as a potential novel therapeutic tool for diabetic wound healing.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.114.304705

PubMed ID

  • 25395617

Additional Document Info

start page

  • 163

end page

  • 74

volume

  • 35

number

  • 1