Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin Academic Article uri icon

Overview

MeSH Major

  • Anthelmintics
  • Benzimidazoles
  • Hippocampus
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Neurons
  • Tubulin

abstract

  • These studies demonstrate that tubulin-binding drugs can activate a component of the hypoxic adaptive response, specifically the stabilization of HIF-1α and its downstream targets. Tubulin-binding drugs, including antihelminthic benzimidazoles, also abrogate oxidative neuronal death in primary neurons. Given their safety in humans and known ability to penetrate into the central nervous system, antihelminthic benzimidazoles may be considered viable candidates for treating diseases associated with oxidative neuronal death, including stroke.

publication date

  • January 10, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4281859

Digital Object Identifier (DOI)

  • 10.1089/ars.2013.5595

PubMed ID

  • 24766300

Additional Document Info

start page

  • 121

end page

  • 34

volume

  • 22

number

  • 2