Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons Academic Article uri icon

Overview

MeSH Major

  • Irritable Bowel Syndrome
  • Neurons
  • Submucous Plexus

abstract

  • These data provide evidence that factors present in IBS plasma modulate neuronal activity in the submucosal plexus and that this is likely to involve CRFR1 activation and IL-6 signalling. These neuromodulatory actions of stress and immune factors indicate a potential mechanism by which immune activation during periods of stress may lead to symptom flares in IBS.

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.bbi.2014.08.005

PubMed ID

  • 25150006

Additional Document Info

start page

  • 57

end page

  • 67

volume

  • 44