Nitric oxide regulates synaptic transmission between spiny projection neurons Academic Article uri icon


MeSH Major

  • Basal Ganglia
  • Guanylate Cyclase
  • Neurons
  • Nitric Oxide
  • Synaptic Transmission
  • gamma-Aminobutyric Acid


  • Recurrent axon collaterals are a major means of communication between spiny projection neurons (SPNs) in the striatum and profoundly affect the function of the basal ganglia. However, little is known about the molecular and cellular mechanisms that underlie this communication. We show that intrastriatal nitric oxide (NO) signaling elevates the expression of the vesicular GABA transporter (VGAT) within recurrent collaterals of SPNs. Down-regulation of striatal NO signaling resulted in an attenuation of GABAergic signaling in SPN local collaterals, down-regulation of VGAT expression in local processes of SPNs, and impaired motor behavior. PKG1 and cAMP response element-binding protein are involved in the signal transduction that transcriptionally regulates VGAT by NO. These data suggest that transcriptional control of the vesicular GABA transporter by NO regulates GABA transmission and action selection.

publication date

  • December 9, 2014



  • Academic Article



  • eng

PubMed Central ID

  • PMC4267338

Digital Object Identifier (DOI)

  • 10.1073/pnas.1420162111

PubMed ID

  • 25413364

Additional Document Info

start page

  • 17636

end page

  • 41


  • 111


  • 49