Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: The impact of APOE and smoking Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Apolipoprotein E4
  • Breast Neoplasms
  • Cognition Disorders
  • Smoking

abstract

  • The association between APOE status, breast cancer treatment, and cognitive functioning was moderated by smoking history suggesting that both chemotherapy and endocrine therapy interact with APOE status and smoking to influence cognition. A putative mechanism is that smoking corrects a deficit in nicotinic receptor functioning and dopamine levels in APOE4+ individuals.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4214914

Digital Object Identifier (DOI)

  • 10.1002/pon.3545

PubMed ID

  • 24789331

Additional Document Info

start page

  • 1382

end page

  • 90

volume

  • 23

number

  • 12